Level of study
BAC +3
ECTS
5 credits
Component
Faculty of Science
Description
Functional genetics aims to better understand the relationships between genotype and phenotype. This course integrates the different aspects of the analysis of gene and genome function at the whole genome level by in vivo approaches, as well as transcriptional regulation and expression regulation of eukaryotic genomes. The course is illustrated by concrete examples in developmental genetics in physiological and pathological contexts.
Objectives
-Knowledge:
Concepts and methods for understanding the phenotype-genotype relationship
Gene structure: coding versus non-coding regions, Cis-Trans effects
Regulation of eukaryotic gene expression
Genetic screens and model organisms (forward genetics)
Techniques for generating genetically modified organisms (reverse genetics)
-Know-how :
Use of DNA manipulation techniques and generation of genetically modified organisms
Interpretation of genetic analysis results
-Know how to be :
Ethical behavior (use of model organisms, plagiarism, cheating in science...)
Ability to methodically analyze genetic analysis results
Be pragmatic
Be curious
Necessary pre-requisites
MENDELIAN GENETICS, NOTIONS IN POPULATION AND HUMAN GENETICS