• Level of study

    BAC +3

  • ECTS

    3 credits

  • Component

    Faculty of Science

Description

Systems biology offers the possibility of understanding the functioning of living organisms at different scales of their organization. This course will focus on the subcellular scale. At this scale, systems biology models integrate several levels of interaction from the transcriptome, proteome, metabolome. The predictions of in silico models can be used in biomedical research to understand multi-factorial diseases and optimize drug treatments, in bioengineering to synthesize genomes with optimized properties and functions (synthetic biology), as well as to guide fundamental research on the principles of the functioning of living organisms. The course consists of a theoretical part (lectures and tutorials on the modeling of gene, signaling and metabolic networks) and a practical part (computer exercises using Matlab software).

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Objectives

- understand mathematical models of gene, signaling and metabolic networks.

- be able to use the basic principles of systems biology (networks and regulatory circuits, stability and robustness, dynamic systems and their attractors, emergent properties) in reasoning about biological systems.   

- use this understanding to integrate multimodal biological data and optimize bioscience treatments.

- acquire basic programming skills in Matlab, use of model repositories and systems biology exchange formats.

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Necessary pre-requisites

HAV626V Mathematics for Biology

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